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Health Economic Evidence for Liquid- and Tissue-based Molecular Tests that Inform Decisions on Prostate Biopsies and Treatment of Localised Prostate Cancer: A Systematic Review
Cancer Health Services Research, Centre for Cancer Research, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, AustraliaCancer Health Services Research, Centre for Health Policy, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia
Cancer Health Services Research, Centre for Cancer Research, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, AustraliaCancer Health Services Research, Centre for Health Policy, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia
Department of Urology, Frankston Hospital, Frankston, AustraliaDepartment of Surgery, The University of Melbourne, Melbourne, AustraliaDivision of Urology, Royal Melbourne Hospital, Melbourne, Australia
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USAInstitute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USAJonsson Comprehensive Cancer Centre, University of California, Los Angeles, Los Angeles, CA, USADepartments of Human Genetics and Urology, University of California, Los Angeles, Los Angeles, CA, USADepartment of Medical Biophysics, University of Toronto, Toronto, Canada
USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USADepartment of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USANorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Cancer Health Services Research, Centre for Cancer Research, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, AustraliaCancer Health Services Research, Centre for Health Policy, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, AustraliaDepartment of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, AustraliaHealth Technology and Services Research, Faculty of Behavioural, Management and Social Sciences, Technical Medical Centre, University of Twente, Enschede, The Netherlands
Several liquid- and tissue-based biomarker tests (LTBTs) are available to inform the need for prostate biopsies and treatment of localised prostate cancer (PCa) through risk stratification, but translation into routine practice requires evidence of their clinical utility and economic impact.
Objective
To review and summarise the health economic evidence on the ability of LTBTs to inform decisions on prostate biopsies and treatment of localised PCa through risk stratification.
Evidence acquisition
A systematic search was performed in the EMBASE, MEDLINE, Health Technology Assessment, and National Health Service Health Economic Evaluation databases. Eligible publications were those presenting health economic evaluations of an LTBT to select individuals for biopsy or risk-stratify PCa patients for treatment. Data on the study objectives, context, methodology, clinical utility, and outcomes were extracted and summarised.
Evidence synthesis
Of the 22 studies included, 14 were focused on test-informed biopsies and eight on treatment selection. Most studies performed cost-effectiveness analyses (n = 7), followed by costing (n = 4) or budget impact analyses (n = 3). Most (18 of 22) studies concluded that biomarker tests could decrease health care costs or would be cost-effective. However, downstream consequences and long-term outcomes were typically not included in studies that evaluated LTBT to inform biopsies. Long-term effectiveness was modelled by linking evidence from different sources instead of using data from prospective studies.
Conclusions
Although studies concluded that LTBTs would probably be cost-saving or -effective, the strength of this evidence is disputable because of concerns around the validity and transparency of the assumptions made. This warrants prospective interventional trials to inform health economic analyses to ensure collection of direct evidence of clinical outcomes based on LTBT use.
Patient summary
We reviewed studies that evaluated whether blood, urine, and tissue tests can reduce the health and economic burden of prostate cancer. Results indicate that these tests could be cost-effective, but clinical studies of long-term outcomes are needed to confirm the findings.
Distinguishing between indolent and aggressive tumours remains a challenge in the diagnosis and management of localised prostate cancer (PCa). Existing clinical prognostic assays, such as digital rectal examination (DRE) and serum levels of prostate-specific antigen (PSA), have limited specificity and sensitivity for early identification of aggressive tumours. Together with the lack of comprehensive liquid biopsies in PCa care, this is leading to many tissue biopsies and repeat biopsies that have substantial cost and clinical complications, such as bleeding and infection, leading to major health and economic burdens on patients and society. Given that a minority of all PCas diagnosed represent life-threatening disease and that tissue biopsies have limited precision in predicting the clinical course of the disease, the health and economic burden for PCa patients and society is further increased by overdiagnosis that may lead to overtreatment [
To reduce the burden of PCa, prospective evidence suggests that patients with low and favourable intermediate risk PCa (PSA <10 ng/ml and Gleason ≤ 3 + 4 [grade group 2]) may be managed through active surveillance (AS) [
]. The ProtecT study randomised 1643 patients with screen-detected PCa, of whom approximately 80% had low or favourable intermediate risk, to AS, radical prostatectomy, or radiotherapy as the initial management strategy [
]. After median follow-up of 10 yr, radical treatment reduced the risk of disease progression, but a significant difference in PCa-specific or overall survival was not observed. Despite these results and the common complications associated with radical treatments that substantially impact quality of life [
], several real-world studies have shown that only 30–50% of patients with low risk and 10–15% of those with intermediate risk are initially managed with AS in the USA, Germany, and Australia [
A retrospective analysis of Victorian and South Australian clinical registries for prostate cancer: trends in clinical presentation and management of the disease.
Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: a National Cancer Data Base analysis 2004 to 2013.
]. This suggests that both under- and overtreatment of PCa continue to pose a substantial health and economic burden on patients and society.
To better target treatment and to reduce the number of tissue biopsies, liquid and tissue-based biomarker tests (LTBTs) have been developed to improve risk stratification of (suspected) localised PCa. These tests have two specific applications in the context of localised PCa by predicting whether patients harbour an aggressive tumour: (1) they indicate which patients should undergo a repeat biopsy after an initial negative biopsy and (2) they indicate which patients are candidates for AS and which are most likely to benefit from active treatment, such as radical or systemic treatment. Although several LTBTs are authorised on the basis of extensive validation studies and are commercially available, they have not yet been studied in prospective interventional trials and are not strongly recommended for localised disease in clinical guidelines of leading professional societies, such as the European Association of Urology, American Urology Association, and American Society for Clinical Oncology [
]. The National Comprehensive Cancer Network (NCCN) recommends consideration of biomarkers in selecting individuals for a prostate biopsy to improve the specificity of screening [
]. The NCCN does not recommend routine use of biomarkers for informing decisions on treatment, but suggests that patients with low- and favourable intermediate-risk PCa may consider use of the tissue-based Decipher, Oncotype Dx, and Prolaris tests during initial risk stratification [
In addition to evidence on the clinical utility of LTBTs in improving outcomes, health economic evidence is required to justify the costs of these tests to ensure successful translation to widespread clinical use. Many countries around the world, such as the UK, Canada, and Australia, require evidence on the cost-effectiveness or “value for money” of health care technologies before their use is reimbursed by public health care systems. Although recent clinical-evidence reviews of these tests have suggested the need to include cost-effectiveness [
], a formal appraisal of the health economic evidence for test-informed management of PCa is lacking. We sought to fill this gap and provide a basis for future study design enabling economic evaluations of LTBT by reviewing the current health economic evidence on the use of LTBTs to inform the need for a (repeat) biopsy or treatment decisions for localised PCa.
2. Evidence acquisition
The review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines [
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
]. A protocol for this review was not published before it was conducted.
2.1 Eligibility criteria
Eligible publications were those reporting on model- or trial-based health economic evaluations of a liquid- (including urine and blood) or tissue-based test to select individuals for a prostate biopsy or to risk-stratify patients with localised PCa for treatment. The study was not limited to full economic evaluations such as cost-benefit and -effectiveness analyses, and included costing studies (ie, cost per patient as the main outcome) and budget impact analyses (ie, population-level cost as the outcome). A test was considered to inform biopsies if it informed the decision to perform prostate biopsies in PCa patients or individuals who are suspected of having PCa based on PSA and DRE. This included the use of tests to inform the need for biopsies for patients on AS following diagnosis of a presumed clinically insignificant cancer. A test was considered to risk-stratify patients for treatment if it informed treatment decisions, including decisions regarding adjuvant treatment. Only full-text publications written in English were included. Publications investigating standard PSA only were not eligible for inclusion. Studies investigating PSA-based tests beyond standard PSA, such as percent free PSA and PSA density, were eligible for inclusion. Other publications not eligible for inclusion were those focusing on screening or metastatic disease, cost-of-illness studies, reviews, commentaries, letters, conference abstracts, and those evaluating management options only. No restrictions regarding the year of publication were applied.
2.2 Search strategy and study selection
The literature search was performed on September 16, 2020 using the Ovid platform to access the EMBASE, MEDLINE, Health Technology Assessment, and National Health Service Health Economic Evaluation Database platforms. Each database was searched individually using four sets of free-text terms to identify publications on (1) PCa, (2) economic evaluations, and (3) tests, and (4) to exclude publications on screening and metastatic PCa. Only generic terms were used to identify LTBTs; no specific biomarker or test names were used to avoid selection bias based on prior knowledge of certain biomarkers or tests. Subject headings were considered but were not included in the final search strategy. No exclusion criteria were enforced during the search to avoid erroneous exclusion of eligible publications. The final database-specific searches are presented in Supplementary Tables 1–4.
Two reviewers (K.D. and A.P.S.) independently screened titles and abstracts of 150 publications to check for consistency, after which one reviewer (K.D.) completed the screening. The full texts of included publications were independently reviewed by the same two reviewers for final inclusion or exclusion. Disagreements between reviewers were resolved via consensus. Publications were excluded if they were not full-text articles (eg, conference abstract), not about PCa, not a health economic evaluation of a LTBT, or if they focussed on imaging only. The references of publications included were screened for further articles of interest.
2.3 Data extraction and synthesis
One reviewer (K.D.) extracted data from all the publications included using a predefined data extraction template. Information was extracted for year of publication, journal of publication, source(s) of funding, conflict(s) of interest, test(s) considered, test application (ie, inform biopsies or treatment), patient population, type of health economic analysis, health outcomes considered, strategies compared, study perspective, geographical location, type of analysis (ie, trial- or model-based), time horizon, cost indexing year, discount rates, modelling technique, model structure, model validation efforts, sensitivity analyses performed, uncertainty analyses performed, evidence approach, evidence for diagnostic performance, evidence for health outcomes, evidence for impact on clinical management, evidence on patient preferences, economic outcomes, and health outcomes.
In terms of data synthesis, journals of publication were classified according to their subject areas as medical, health policy, or multidisciplinary according to their subject area and category on SCImago Journal & Country Rank (www.scimagojr.com/). Potential conflicts of interests were determined according to the (industry) funding source and whether any author had industry or consultancy affiliations. The health economic analyses were categorised as costing, budget impact, or cost-effectiveness analyses, with multiple categories potentially applicable per publication. Comparators were classified as standard of care (SOC), including a test, or other (eg, when including imaging only). Health and economic outcomes were summarised according to whether test use increased or decreased costs and health outcomes and, for cost-effectiveness studies, whether their use was considered cost-effective by the original authors. Increases in health outcomes of less than 0.05 quality-adjusted life years (QALYs) were considered negligible increases. Although arbitrary, this threshold was selected and used to synthesise the evidence into a format informative to readers, in other words, to indicate whether the difference was considered meaningful. The threshold is not a measure of statistical significance, as significance would relate to the certainty rather than the magnitude of the difference in QALYs.
2.4 Risk of bias and quality of evidence
In the absence of an established method for assessing bias and methodological quality in health economic studies, the risk of bias in publications and the appropriateness of the methods was assessed as part of the evidence synthesis on the basis of the study methods and evidence used. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist was used to assess the quality of reporting [
Consolidated Health Economic Evaluation Reporting Standards (CHEERS)—explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force.
]. Although the CHEERS checklist was developed as a checklist rather than a quality scoring tool, it has been widely used to assess the quality of reporting for health economic studies in the absence of better alternatives. For each publication, we assessed which CHEERS items were applicable and whether those were reported. A score for the quality of reporting of a publication on a scale from 0% to 100% was defined as the proportion of applicable items reported compared to the total number of applicable CHEERS items.
3. Evidence synthesis
The literature search yielded 1535 publications, of which 317 were identified as duplicates (Fig. 1 and Supplementary Tables 1–4). Of the 1218 unique publications, 1140 were excluded on the basis of title and abstract. After assessment of the full text of the remaining 78 publications, 58 were excluded for varying reasons, most commonly because of an inappropriate article format or because it was a study only evaluating multiparametric magnetic resonance imaging (mpMRI; Fig. 1). After adding two publications to the sample based on cross-referencing, the final number of publications included for data extraction was 22.
Fig. 1PRISMA flowchart of the study selection process.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
], that is, whether an initial or repeat biopsy was to be performed, whereas eight studies (36%) focused on the use of tests for risk stratification to inform treatment decisions [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. Table 1, Table 2 provide an overview of a subset of the data extracted for tests aimed at informing biopsies and treatment of PCa, respectively. An overview of all the data extracted is provided in Supplementary Tables 5 and 6. An overview of the tests evaluated and their characteristics is provided in Table 3. Note that one study considered a hypothetical test [
Table 1Overview of the data extracted for 14 health economic studies on liquid- or tissue-based tests to inform decisions on the need for a prostate biopsy
A dominant strategy improves health outcomes at lower costs, so it is better in terms of health and economic outcomes, whereas a cost-effective strategy improves health outcomes at higher costs, but the increase in costs is considered proportionate to the improvement in health, so the improvement in health is worth the increase in costs.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
BIA = budget-impact analysis; CA = cost analysis; CEA = cost-effectiveness analysis; DMA = decision-making aim; Bx = biopsy; NA = not applicable; PSA = prostate-specific antigen; pfPSA = percent free PSA; UPA-P = urinary proteome analysis for prostate cancer; PHI = Prostate Health Index; EPI = ExoDx Prostate Intelli-Score; PSAd = PSA density; SOC = standard of care; mpMRI = multiparametric magnetic resonance imaging; CCs = cancer cases; QALYs = quality-adjusted life years; MBSS = modelling based on sensitivity and specificity; DT = decision tree; STM = state-transition model; DES = discrete event simulation.
a Impact here refers to both health and economic outcomes for CEAs and economic outcomes for CAs or BIAs.
b Obtained via cross-referencing.
c A dominant strategy improves health outcomes at lower costs, so it is better in terms of health and economic outcomes, whereas a cost-effective strategy improves health outcomes at higher costs, but the increase in costs is considered proportionate to the improvement in health, so the improvement in health is worth the increase in costs.
Table 2Overview of data extracted data for eight health economic studies on liquid- or tissue-based tests to facilitate treatment decisions for localised prostate cancer
A dominant strategy improves health outcomes at lower costs, so it is better in terms of health and economic outcomes, whereas a cost-effective strategy improves health outcomes at increased costs, but the increase in costs is considered proportionate to the improvement in health, so the improvement in health is worth the increase in costs.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
BIA = budget-impact analysis; CA = cost analysis; CEA = cost-effectiveness analysis; DMA = decision-making analysis; TS = treatment strategy; NA = not applicable; NOS = not otherwise specified; RP = radical prostatectomy; HR = high risk; IR = intermediate risk; LR = low risk; SOC = standard of care; QALYs = quality-adjusted life years; OBS = observational study; DT: decision tree, STM: state-transition model.
a Impact here refers to both health and economic outcomes for CEAs and economic outcomes for CAs or BIAs.
b A dominant strategy improves health outcomes at lower costs, so it is better in terms of health and economic outcomes, whereas a cost-effective strategy improves health outcomes at increased costs, but the increase in costs is considered proportionate to the improvement in health, so the improvement in health is worth the increase in costs.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
mRNA levels of 22 genes involved in cell differentiation, proliferation, adhesion, motility, structure, cell-cycle progression, mitosis, immune modulation, and other unknown function
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Detailed scoring of the studies according to the CHEERS checklist is presented in Supplementary Table 7. On average, the studies included reported 81% of the applicable items (median 80%, range 64–100%). CHEERS items that were not appropriately reported by 20% or more of the studies to which they were applicable included: title; setting and location; effectiveness measure; health-related quality-of-life population; currency and conversion; characterisation of uncertainty; source of funding; and conflicts of interest. On average, publications in health policy journals reported more CHEERS items (87%) compared to papers in medical and multidisciplinary journals (79%). Although this finding is concordant with previous reviews of health economic studies [
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
]. Five of the cost-effectiveness analyses used QALYs as the effectiveness outcome, which is the gold-standard effectiveness outcome in health economics as it allows for comparison across diseases. Twelve of 14 studies adopted a health care payer perspective. Nine studies (64%) considered a time horizon of 3 yr or shorter. All studies were model-based, with decision tree analysis the technique most frequently used (n = 7, 50%). Six studies considered treatments in their model structure [
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Eleven out of 14 studies (79%) modelled test outcomes and subsequent management decisions based on the sensitivity and specificity of the tests and linked those test outcomes to health and economic outcomes, whereas two studies used observational data on diagnosis patterns and linked those to health and economic outcomes [
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
], although for that study the effectiveness outcome was not QALYs but the number of missed cancer cases and unnecessary biopsies. All studies assumed perfect compliance with the test recommendations, that is, clinician or patient preferences and practice variations were not considered.
Eleven out of 13 studies (85%) found the use of tests to be cost-saving [
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
], of which those performing cost-effectiveness analyses found the use of tests cost-effective or dominant, that is, preferable in terms of effectiveness and costs. Two of these 13 studies (15%) found that the use of tests would increase costs [
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
]. One of these was the only official health technology assessment report, concluding that the use of two tests (evaluated separately) was not cost-effective [
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
]. The study that evaluated a hypothetical test for different subgroups found mixed results, but overall concluded that use of a test would be cost-effective [
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. One study compared a test-informed strategy to strategies in which all patients would either enrol in a surveillance strategy or undergo prostatectomy in the initial treatment phase [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. All cost-effectiveness analyses were performed using QALYs as the effectiveness outcome. All studies adopted a health care payer perspective. Single studies considered a time horizon of 180 d [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. All state-transition models were structured according to health states, whereas the structure of the decision tree was mainly defined by the different treatment options. Three of the seven model-based analyses (43%) presented external validation for specific parts of the model [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Seven of the eight studies (88%) mainly used observational data to link health and economic outcomes to observed treatment decisions based on test results [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. All six cost-effectiveness analyses modelled effectiveness outcomes based on the literature. Two studies (25%) assumed perfect compliance with test recommendations [
], that is, clinician or patient preferences as a source of practice variation were not considered, which is not expected to be realistic. The other studies accounted for variation in following test recommendations in the real world, but to varying extents: five modelled treatment patterns as found in the observational data used [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
]. No study explicitly considered patient preferences regarding treatment options, but the observational data used in four studies do include this real-world variation [
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
]. All cost-effectiveness analyses found that LTBT use results in better health outcomes, although this increase was considered to be relatively small in magnitude for two studies by the reviewers [
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of a biopsy-based 8-protein prostate cancer prognostic assay to optimize treatment decision making in Gleason 3 + 3 and 3 + 4 early stage prostate cancer.
Cost-effectiveness of the Decipher Genomic Classifier to guide individualized decisions for early radiation therapy after prostatectomy for prostate cancer.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
We systematically reviewed 22 health economic studies evaluating 17 different molecular tests aimed at informing the need for a (repeat) biopsy or treatment decisions for localised PCa. Overall, these studies suggest that LTBT use to inform the need for prostate biopsies and the treatment of PCa can be either cost-saving or -effective. In particular, tests aimed at informing biopsy decisions were found to result in cost savings because of a lower number of prostate tissue biopsies performed. LTBT use to inform treatment decisions could potentially be cost-effective, that is, they improve health outcomes at an acceptable increase in cost, according to the authors. The encouraging results from these studies, however, do not align with the current uptake of tests in clinical guidelines or routine practice outside the USA. This discordance is likely to be caused by the absence of prospective interventional clinical studies on which health economic evaluations should be based. In addition, our review identified methodological challenges explaining why the current studies provide insufficient evidence for health care decision-makers to justify the incremental costs. These mainly relate to the short time horizons for which outcomes are evaluated, including how use of these tests will impact clinical management in subsequent stages of the disease, and several structural model assumptions.
The studies that evaluated LTBT use to inform the need for invasive tissue biopsies had a particularly narrow focus in terms of downstream health outcomes and costs. For example, most of these studies adopted short-term time horizons and ignored the impact of false-negative test results or accounted for it in a limited way. The clinical utility of LTBTs in changing management was not considered in these studies at all and only indirectly in some studies focusing on PCa treatment. Ignoring these aspects may results in cost-effectiveness estimates that are biased in favour of tests, as a previous modelling study in advanced PCa demonstrated that compliance with test results may have a substantial impact on health economic outcomes [
Comparison of timed automata with discrete event simulation for modeling of biomarker-based treatment decisions: an illustration for metastatic castration-resistant prostate cancer.
]. Although studies focusing on treatment of PCa overall more extensively accounted for downstream consequences, the number of studies was low and they focused on specific tests, leaving the overall judgement on the cost-effectiveness of tests in this context uncertain.
Given the lack of prospective comparative evidence, the studies reviewed can be considered early-stage health economic evaluations that are neither designed nor suitable for providing definitive evidence for reimbursement. Nevertheless, these early economic models can inform further translation of tests and treatments by prioritising additional clinical studies [
]. Despite being early-stage evaluations, overall the studies appraised provided insufficient justification of the evidence, model structures, and techniques used. This is in line with other reviews of health economic studies in oncology [
] reviewed five full economic evaluations of mpMRI for the diagnosis prostate cancer and found substantial heterogeneity in the questions posed, pathways modelled, and assumptions made. They concluded that there is a need for a better standard of reporting around key modelling assumptions and a wider range of sensitivity analyses to explore the impact of structural assumptions and to reflect uncertainty around data inputs for the model parameters. We suggest that transparent reporting may be even more important for early-stage analyses specifically, as these often require a larger number and intensity of assumptions based on more limited evidence. Previous studies have additionally discussed a deficiency of policies for health economic analyses, as well as a lack of reviewers with knowledge of health economics, urging journals to provide authors and reviewers with guidance on cost-effectiveness studies [
]. Given that the vast majority of studies included in this review were published in medical journals and that reporting quality was found to be lower in those journals compared to health policy journals according to the CHEERS checklist, this may have contributed to the lack of justification identified.
Despite the overall positive findings, the issues highlighted above suggest that health economic estimates may be overoptimistic and that, consequently, the cost-effectiveness of test-informed management of PCa is promising but warrants additional research through prospective interventional studies. The observation that three out of eight studies without industry involvement had an overall negative conclusion (38%) compared to only one out of 14 studies with clear industry involvement (7%) may further add to scepticism about the strength of the currently available health economic evidence. This also highlights the need for investigator-initiated clinical studies to strengthen the evidence base for long-term health outcomes. Although controlled interventional studies are as necessary for biomarkers as they are for pharmaceuticals from a health economic perspective, consideration should be given to appropriate regulatory protection to ensure investments are protected following positive study results.
To advance the translation of tests on the basis of health economic evidence, future studies should be aware of several opportunities, most of which relate to the perception that tests should not be considered in isolation but as part of the broader clinical pathway. First, economic evaluations should be considered from an early stage in the development process to collect as much relevant information along the way, which could reduce the number of assumptions that need to be made in the health economic evaluation. Second, studies focusing on the use of tests in the diagnostic process should collect data on how the test will be used in practice, or at least explore the impact of compliance to test results in sensitivity analyses, and realistically account for downstream consequences of false-negative test results. Third, studies focusing on the management of PCa should at least aim to collect data on the impact on actual decisions made and consequent long-term health through observational studies. Fourth, uncertainty in outcomes should be explored and reported more transparently in terms of both model parameters and model assumptions and structure, rather than just in terms of one-way sensitivity analysis of selected parameters. Finally, studies should use existing reporting checklists, such as the CHEERS checklist [
Consolidated Health Economic Evaluation Reporting Standards (CHEERS)—explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force.
], to improve reporting on health economic evaluations.
Further research could also investigate the potential of LTBTs to identify asymptomatic metastatic disease during the diagnostic process. Such early detection could lead to downstaging and, hence, better long-term health outcomes.
This review has certain limitations. Its findings are subject to publication bias, as not all studies may have been published, especially studies with negative findings regarding the cost-effectiveness of tests. The risk of publication bias is highlighted by the substantial number of conference abstracts that were excluded during full-text screening, as full-text publications may not have been pursued for studies with negative findings. The CHEERS checklist was used to appraise the reporting quality of publications in the absence of a better alternative, but this checklist was not designed to score publications and using it to do so may be considered subjective. In terms of data extraction, the lack of clear reporting and justification of methods, modelling assumptions, and analyses performed might have resulted in categorisations that readers or the authors of the original papers might not fully agree with. Finally, some studies presented a range of analyses that had to be summarised into a single cost-effectiveness judgement at the discretion of the reviewers.
4. Conclusions
This review found that most health economic studies concluded that LTBTs can be cost-saving or -effective when used to select individuals for prostate biopsies or to inform decisions on the treatment of confirmed localised PCa through risk stratification. These findings warrant further research through prospective interventional studies to provide robust data on clinical utility and long-term health outcomes that will be essential to strengthen the health economic evidence base. Such information will be crucial to optimise reimbursement of the most cost-effective tests by public health care systems so that outcomes can be improved for the broader population.
Author contributions: Koen Degeling had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: IJzerman.
Acquisition of data: Degeling, Pereira-Salgado.
Analysis and interpretation of data: Degeling, Pereira-Salgado, Corcoran, Boutros, Kuhn, IJzerman.
Drafting of the manuscript: Degeling.
Critical revision of the manuscript for important intellectual content: Pereira-Salgado, Corcoran, Boutros, Kuhn, IJzerman.
Statistical analysis: Degeling.
Obtaining funding: Corcoran, IJzerman.
Administrative, technical, or material support: None.
Supervision: IJzerman.
Other: None.
Financial disclosures: Koen Degeling certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: Maarten J. IJzerman has received research support from Illumina Inc. for projects related to whole-genome sequencing and liquid biopsies. Paul C. Boutros sits on scientific advisory boards for BioSymetrics Inc. and Intersect Diagnostics Inc. Peter Kuhn is a royalty recipient, shareholder, and advisor of Epic Sciences. The remaining authors have nothing to disclose.
Funding/Support and role of the sponsor: This work was part of the PRECEPT program funded by the Prostate Cancer Research Alliance, which is a joint initiative between the Movember Foundation and the Australian Government. Peter Kuhn is supported by NCI Cancer Center support grant P30 CA014089.
Acknowledgments: The authors would like to acknowledge Ms. Julia S. Hofkes for her contribution to an initial version of this review.
Data sharing statement: All data generated or analysed during this study are included in this published article and its supplementary information files.
Appendix A. Supplementary data
The following is Supplementary data to this article:
A retrospective analysis of Victorian and South Australian clinical registries for prostate cancer: trends in clinical presentation and management of the disease.
Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: a National Cancer Data Base analysis 2004 to 2013.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
Consolidated Health Economic Evaluation Reporting Standards (CHEERS)—explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force.
The clinical effectiveness and cost-effectiveness of the PROGENSA prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.
Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics – a decision analytical model.
Use of the 4Kscore test to predict the risk of aggressive prostate cancer prior to prostate biopsy: overall cost savings and improved quality of care to the US healthcare system.
Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4–10 in Hong Kong.
Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study.
A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.
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