Introduction and Objectives
Retrospective evaluation of patients surviving with positive pelvic lymph nodes (N1) after radical prostatectomy (RPE).
Material and Methods
We have retrospectively evaluated 325 patients, who underwent RPE in our hospital since 1998 to 2006. Overall follow up was 3 to 10 years. Our interest was focused on patients with unexpected finding of positive lymph nodes in histological specimen after RPE. We evaluated outcomes of adjuvant treatment (PSA level) and survival of patients.
Ten patients (3%) had a carcinoma infiltration of lymph nodes; their average PSA level was 11.8 before radical prostatectomy. Their average age was 65 years. Gleason score 6 was in 6 patients, 7 was in 4 patients and 8–10 was in 5 patients. Sequential radiotherapy combined with hormonal treatment was used in 7 patients and 2 patients underwent the only androgen deprivation. One patient refused sequential treatment. No patient died for prostate cancer. Seven patients are in long-time remission with PSA < 0.1. Three patients are with slow progression (DT). Patient, who refused a treatment, is in a long-time remission with PSA < 0.1.
Infiltration of pelvic lymph nodes is a poor prognostic factor. An adjuvant treatment would be indicated. Use of adjuvant oncological treatment can achieve a long-time remission and survival of patient.
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.