Introduction and Objectives
The present study was designed to prove if changes of glomerular Filtration rate (GFR) measured by dynamic Inulin-, as well as, creatinine-clearance (crea-Cl), lipid peroxidation assessed by plasma malondialdehyde (MDA) level And antioxidant system substantiated by plasma total antioxidant status (TAS) And serum total thiols (RSH) can be observed after ESWL-treatment of kidney Stones.
Material and Methods
Eleven patients (2 females/9 males), 51 years of age as average, (range: 25 to 69), having nonsymptomatic kidney stones and no ESWL-therapy within One year, were eligible for inclusion. All patients underwent a single unilateral treatment By Dornier Doli S Lithotripter. The average number of shocks (sh) was 4000 (3000 to 4060sh) with an energy of 70%. For the evaluation sampling of blood and urine was undertaken three hours before SWL treatment, 1 hour, and 24 hours after SWL treatment.
Eleven patients undergoing (their) first unilateral lithotripsy, for kidney Stones showed a decrease of GFR (p <0.001) immediately after therapy, Which normalised to baseline level during 24 hours, while the values of crea- Cl remained unchanged (p <0.46). Moreover, levels of RSH measured one hour After ESWL showed a decrease (p <0.01), the levels of MDA demonstrated Statistically significant changes at the same time(p 0,058), while levels of TAS remained unchanged(p 0.17). Another important finding were increased Levels of MDA (p < 0.05) and reduced levels of TAS (p <0.17) and RSH (p <0.017) at baseline.
Our results suggest that patients with renal stones suffer from Increased oxidative stress, compared to healthy population. ESWL induces the Production of shock wave generated free radicals determined by the Consumption of antioxidant substances. The measurement of GFR showed a Temporary decrease in renal function after lithotripsy but restitution to baseline Values until the next day.
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.