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C11 Is treatment of haemorrhagic radiation cystitis with hyperbaric oxygen (HBO) effective?

      Introduction and Objectives

      To evaluate the efficacy of HBO on patients who were irradiated because of pelvic organ malignancies, and developed haemorrhagic radiation cystitis.

      Material and Methods

      We reviewed retrospectively 14 patients from 2001 -2007 with different pelvic organ malignancies, who developed radiation cystitis after irradiation. Patient groups were divided into 2 groups, group 1 (treatment group, n = 10), and group 2 (control group, n = 4). Before therapy chest X ray was done, every patient was examined by E.N.T and internal medicine specialist. 14 patients were entered into our study, and 10 patients were treated for at least 1 month with hyperbaric oxygen. In group 1, mean age was 79 (range: 59–90). 7/10 (70%) males had prostate cancer, every patient received 70 Gy. 3/10 (30%) females, one had colon cancer (50 Gy), one had cancer of Vulvae (50 Gy), one had cervical cancer (56 Gy). In group 2 mean age was 63 years (range: 51–79 years), 3/4 (75%) males had prostate cancer; 1/4 (25%) female had uterus cancer (30 Gy). In group 1 follow up was 1–6 years, mean follow up was 18 months.

      Results

      In group 1, 2/10 (20%) patients haemorrhage stopped, 3/10 (30%) patients were operated (transurethral coagulation, embolisation of the internal iliac artery), 5/10 (50%) patients needed repeatedly erythrocyte concentrates and urinary catheters. In group 2, 2/4 (50%) patients bleeding stopped spontaneously, 1/4 (25%) patient was operated (transurethral coagulation), 1/4 (25%) patient developed in 5 years additionally cancer of urinary bladder.

      Conclusions

      Our study showed that treatment of haemorrhagic radiation cystitis with hyperbaric oxygen was not effective in the majority of patients.