S141 Preoperative use of ketamine for treatment of acute postoperative pain

To evaluate the effectiveness and the tolerance of Ketamine preoperative of acute postoperative pain. Postoperative pain control is often limited because of the side effects of the narcotics: such as nausea and vomiting. An alternative with non-opioide low-priced drug such as Ketamine could be very effective when used in preoperative phase to increase pain control levels post-operatively and with fewer side effecte.

The study was a controlled randomized. The participants of the study are 150 patients of ages from 18 years old to 75years old, and underwent the urology. All patients were ASA I-II. All subjects were treated with 5 mg of midazolam one hour pre-op. Participants were placed in two groups, the first group received Ketamine 0.5 mg/kg/p and the other group did’nt take Ketamine but placebo sol.isotonic. Saline 0.9%. The analysis was done by two independent MD without any information if the participant had taken Ketamine or placebo. The charts to be reviewed were randomly assigned. This study evaluated hemodynamic parameters such as blood pressure, heart rate, respiratory rate, pain level in scale of 1–10 reported by the participants, and amount of Morphine used to control pain. Furthermore, we evaluated the frequency of side effects. The patients have received one dose of bolus ketamine before incision. All participant did receive endotracheale anesthesia. From the analysis of the 75 patients who received Ketamine was found that the level of pain was reduced, or the time that pain medication was required was extended, or both. reduced the amount of morphine used and furthermore, it decreased side effects such as nausea and vomiting post surgery. Side effects were decreased or were completely absent. Ketamine was used in a low enough dose to prevent the psikomimetike effects Ketamine is an antagonist of NMDA receptor, and specifically blocking of those receptors results on preventing of hyperalgesic effects of the Morphine.

Ketamine in this study is used preoperatively in subanesthetic doses, and has and an analgesic effect on pain control postoperatively. This is shown by the decreased level of Morphine in the first 24 hours post-operation. In addition, Ketamine reduces nausea and vomiting postoperation. Furthermore, other side effects are minimized or not present at all.

Ketamine in this study is used preoperatively in subanesthetic doses, and has and an analgesic effect on pain control postoperatively. This is shown by the decreased level of Morphine in the first 24 hours post-operation. In addition, Ketamine reduces nausea and vomiting postoperation. Furthermore, other side effects are minimized or not present at all.