Poster Session 7: Stone disease| Volume 8, ISSUE 8, P640, September 2009

S97 The effect of metabolic syndrome components on urolithiasis: An epidemiological study

      Introduction and Objectives

      Components of metabolic syndrome, such as obesity, hypertension, and diabetes, are thought to be associated with urolithiasis, but limited published large-scale study has examined the association between metabolic syndrome and urolithiasis. We evaluated the relation between metabolic syndrome components and urolithiasis in a nationwide survey.

      Material and Methods

      A representative sample of 2468 persons aged between 18–70 years in 33 provinces of Turkey was enrolled in the cross-sectional study conducted with a professional investigation company. Participants were evaluated with face to face interviews by medical faculty students. Participants with urolithiasis history (Group 1) were compared participants without urolithiasis history (Group 2) in terms of hypertension, diabetes, body-mass index (BMI), waist size and trouser size using chi-square and odds ratio tests.


      Of the 2468 participants, 274 (11.1%) reported history of urinary stone disease diagnosed by a physician. The percentage of hypertension in participants with urolithiasis was significantly higher than participants without urolithiasis (16.9% & 34.3%, p:0.000, OR:3.0). In group 1, 14.2% and in group 2, 9% of participants had diabetes (p:0.001, OR: 1.83). The mean BMI was 27.2 and 25.2, respectively (p:0.01). Participants with a BMI > 30 had a 2.2 times fold increased risk of having urolithiasis. Moreover, mean waist size was significantly greater in participants with urolithiasis (p:0.000). Those with waist size >100 cm had a 1.87 times fold increased risk of having urolithiasis. The mean trouser size was also significantly bigger in stone formers (p:0.003).


      Metabolic syndrome components are effective factors that play role on the development of urolithiasis.