Introduction and Objectives
To evaluate the relationship between the obesity and prostate cancer.
Material and Methods
From April 2006 and April 2009 864 asymptomatic men with rising PSA underwent extended TRUS guided 12-cores biopsy and the histological examination was made by the same doctor from our pathology department. The median PSA was 5.75 ng/ml (ranged from2.8 to 8.7) and the median age was 62 years(51–73 years).We have investigated the correlation, between obesity(Body Mass Index ≥30 kg/m2) and positive biopsy, Gleason score and PSA. The results analyzed with the SPSS 14.0 Edition.
From our 864 patients, 147 (17%) had obesity (BMI > 30) and 717 (83%) had a normal B.M.I Obese men had median PSA 5.65 ng/ml (8.6–2.7) and median age 60 years (51–71) and men with low Body Mass Index had median PSA 5.77 ng/ml (8.7–2.85) and median age 62.5 years (52–73). From the obesity group, we found prostate cancer in 45 (31%) patients. At the same time of the 717 patients with normal BMI 228 (32%) had prostate cancer (p = 0.01). From the 45 men of the obesity group, six (13%) had Gleason score >7 and from the 228 men with normal BMI only 15 (6.5%) had Gleason score >7 (p = 0.001).
From our results it seems that obesity was not statistical significant related with prostate cancer at the time of biopsy but obese men had a greater likelihood approximately twice to develop a high grade disease.
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.