Introduction and Objectives
BPH is progressive disease, and risk factors for disease progression are well established. In Serbia, compared to other diseases with known risk factors such as Diabetes Mellitus, coronary artery disease or cerebrovascular disease, there is a considerable lack of strategy for prevention of BPH progression. Aim was to determine the risk factors for BPH progression in two groups of men.
Material and Methods
Investigational group of 102 men who complained on LUTS at first visit to urologist, and control group of 109 men who did not complain on LUTS, but came to urologist because of other reason, consisted study group of patients in a survey of LUTS in men aged between 50 to 80 years. Prostate volume and post void residual urine were measured by transabdominal ultrasonography, and PSA was performed for every patient. Uroflowmetry was performed only in selected patients in investigational group.
We found higher PSA values (X2, p < 0.05) and higher prostate volume (X2, p < 0.05) in investigational group. In investigational group 53% and in control group 30% of patients had PSA > 1.5 ng/ml. Prostate volume above 30 ml was found in 55% of patients in investigational, and in 33% of patients in control group. In average patients in investigational group were older than controls. PVR > 100ml was found only in investigational group. Patients with Qmax > 15 ml/sec had lower PSA, prostate volume and PVR compared with patients with Qmax < 10 ml/s. Increasing PSA values with increasing prostate volume as well as increasing PSA values and increasing prostate volume with increasing age were noticed in both groups, but correlation was not statistically analysed because two groups were not age matched due to the study design characteristics.
In attempt to analyze a portion of patients in typical urologists’ office in Serbia, we found that in half of patients who did seek help because of LUTS, and in 1/3 of patients who did not, risk factors for BPH progression were found. This fact emphasizes the significance of comprehensive approach in LUTS patient, bringing them up information's about disease and existing treatment modalities
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.