Introduction and Objectives
Adenocarcinomas of urinary bladder is a rare type of neoplasm and account for 0.5–2 % of all urinary bladder cancers. They can be primary or those arising from urachus. Histologically, adenocarcinomas are mucus secreting and may have glandular, colloid, signet-ring, hepatoid or mixed patterns.
Material and Methods
5 patients were diagnosed as primary urinary bladder adenocarcinomas within the last 4 years in the G.h.of Korinthos.
3 of all patients were 54–85 years old males, with medium grade primary bladder adenocarcinomas which were infiltrating the muscular bladder wall.The rest 2 cases concerned 73 and 76 female patients with low grade muscle infiltrating primary bladder adenocarcinoma. Immunohistochemical examination followed and confirmed the diagnosis demonstrating: CK7 (+), CK20 (+), CK 34βE12 (+), CEA (+), PSA (−), PSAP (−), Vimentin (−). All patients were presented with intermittent macroscopic heamaturia, which was accompanied by symptoms of vesical irritability (frequency, urgency and dysuria) in 4 of them. All patients underwent initially transurethral resection of bladder tumour which was followed by radical cystectomy in 3 of them. In 2 patients identified sites of metastasis at the time of diagnosis.
Primary adenocarcinomas of urinary bladder are quite rare compared to all other types of bladder cancers.They are often localized at the time of diagnosis, but muscle invasion is usually present. Prognosis is poor and 5 year survival is usually less than 40%, despite of aggressive surgical intervention.
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.