Introduction and Objectives
The objectives of this study were to investigate the ACE (Angiotensin-Converting Enzyme Gene) genotype and allels in patients with Ta,T1 and invasive bladder cancer and to evaluate the effect of ACE gene polymorphism on staging (T stage) of bladder cancer.
Material and Methods
ACE genotypes and alleles were determined in 113 patients with histologically confirmed superficially (Ta,T1) and invasive bladder cancer (mean age: 65±11.3 years) and this findings with number of tumor, sex, risk of profession, and smoking history were analysed.
ACE genotypes are distributed in patients with Ta,T1 and invasive tumors as follows; ID is present in 14 (46.7%), DD in 9 (30%), II in 7 (23.3%) patients with Ta tumors, and ID in 19 (42.2%), DD in 16 (35.6%), II in 10 (22.2%) patients with T1 tumors and ID in 15 (39.5%), DD in 15 (39.5%), II in 8 (21.1%) patients with invasive tumors (p > 0.05). I allele was found in 28 (46.7%), 39 (43.3%), 31 (40.8%) in Ta,T1 and invasive tumor respectively (p > 0.05). D allele was found in 32 (53.3%), 51 (56.7%), 45 (59.2%) in Ta,T1 and invasive tumor respectively (p > 0.05). Smoking history, sex, risk of profession, and number of tumor were similar in patients with Ta,T1 and invasive tumor. There were no significant correlation between ACE genotypes and number and size of tumor, sex.
This present study revealed that no significant association between ACE gene polymorphism and staging (T stage) of bladder cancer.
© 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved.