N10 Volume and localization of the prostate tumor as the predictive factors of the prostate cancer stage

  • A.I. Urbansky
    Correspondence author.
    Federal State Institution Russian Research Center For Radiology and Surgical Technologies, Dept. of Pathomorphology, St. Petersburg, Russia
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      Introduction and Objectives

      Tumor volume (TV) is one of the most important prognostic factors in the tumor characteristics and prognosis for the prostate cancer (CaP) patient. Nevertheless, the value of TV as an independent prognostic factor still remains unclear (Bostwick D.G. et al., 2000).To define correlation between the TV, localization and the stage of the CaP analyzing prostate after the radical prostatectomy.

      Material and Methods

      During the last five years in the Federal State Institution Russian research center for radiology and surgical technologies – Petersburg 58 prostates obtained after the radical prostatectomy because of the CaP were analyzed pathomorfologically. Correlation between the prostate gland volume, peripheral zone (PZ) volume and transitory zone (TZ) volume was issued by the definition of appropriate linear coefficients (rxy). Using correlation analysis the data about absolute and relative tumor volume in a prostate gland were compared with pathological stage frequency (pT3).


      Correlation between the percentage of PZ volume and prostate gland volume is significant and inverse (rxy = −0.58), and between the percentage of TZ volume and prostate gland volume is significant and direct (rxy = 0.61). In all patients with adenocarcinoma in TZ the tumor was limited by prostate gland (pT2) in contrast to the patients with adenocarcinoma in PZ (16 from 47 patients had pT3), in spite of less tumor volumein patients with main tumor node in PZ (1.87±0.38 cm3) then in patients with main tumor node in TZ (9.55±8.03 cm3). For adenocarcinoma occupying the 1% of prostate gland volume, probability of pT3 stage is 18%, and in greater tumor volume 10% of probability of pT3 stage increases till 54% (correlating equation y = 0,0289x + 0.0885; R2 = 0.5434).


      Frequency pT3 stage depends on tumor volume predominantly in patients with adenocarcinoma in PZ, because pT3 stage is connected not only with the tumor volume, but also with its localization – more centrally tumor is localized, less probability of pT3 stage it would have. That is why the main role in staging has tumor volume in PZ. PZ volume in prostate gland is the least variable in older men. Risk of pT3 stage is higher in patients with small prostate gland volume. Results of current research could serve as a base for studying a prognosis of a pathological stage by the biopsy results before patients’ distribution on the treatment group.